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Particle perception

We make scientific instruments that detect, quantify and characterize nano-particles in the range of 1-250 nm using high resolution ES-DMA, a form of ion mobility spectrometry.

Our systems offer Angstrom scale resolution, much superior to other ES-DMA and other methods such as IMS, DLS, and NPS.


Our technique is ideal for biological drug characterization including viral vector analytics, antibodies, and vaccines, as well as diagnostic, environmental sciences, and industrial nanoparticle R&D.

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Our systems are primarily used for research & development in areas such as AAV capsid analytics, protein macromolecules, antibodies, structural biology and bioengineering, and climate research.  

To facilitate these areas of R&D, our systems are highly configurable, featuring both liquid and gas sample inputs, the most flexible electro-spray parameters of any system on the market, and multiple downstream accessories including particle counters and collectors.

Learn more about the applications for NanoEngineering's ES-DMA systems.

Medical Research

Our new product, the NanoRanger system, is optimized for research  in viral vector capsid analytics, structural virology, protein macromolecules and other organic metabolites in the range of 5-250 nm.

Environmental Research

Our small particle system, IonRanger, is similar to the NanoRanger except that its DMA is "tuned" for nano-particles in the 1-20nm range, including pollutants and other atmospheric particles of interest, as well as proteins and bio-markers. 


We are focused on advanced ES-DMA as a tool for research & development and production quality control in biological drugs. Electro-spray (ES) Differential Mobility Analysis (DMA) aerosolizes and ionizes a liquid sample, then combines the force of an electrical field and fast flowing air to separate particles by size. 

ES-DMA measures particle size rather than mass or genetic composition.  The method can therefore detect and characterize known and unknown particles, and mass invariant size conformations. Uniquely, ES-DMA can collect sample after separation, with good survival characteristics.  ES-DMA also requires no reagents nor chemical reactions, promising fast results at low cost.

NanoEngineering and Yale University have recently achieved breakthrough advances in DMA resolution, enabling the detection, characterization and collection of particles that vary in size by as little as 2-5 Angstroms. NanoEngineering has focused on commercialization of this technology in the form of a bench-top instrument that runs on wall outlet power, is easy to operate, and requires almost no reagents or consumables.


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